ParkinsonCanadaV1, Main, Exploration, bibRecord, 002D36

Effects of adenosine A1, dopamine D1 and metabotropic glutamate 5 receptors-modulating agents on locomotion of the reserpinised rats

Identifieur interne : 002D36 ( Main/Exploration ); précédent : 002D35; suivant : 002D37

Effects of adenosine A1, dopamine D1 and metabotropic glutamate 5 receptors-modulating agents on locomotion of the reserpinised rats

Auteurs : Naila Ismayilova [Canada] ; Alan Crossman [Canada] ; Alexei Verkhratsky [Canada] ; Jonathan Brotchie [Canada]

Source :

European journal of pharmacology [ 0014-2999 ] ; 2004.

RBID : Pascal:04-0478821

Descripteurs français

Pascal (Inist)
- Lévodopa, Adénosine, Dopamine, Récepteur métabotropique, Récepteur glutamate, Locomotion, Rat, Animal, Récepteur glutamate mglu5, Récepteur adénosinique, Récepteur dopaminergique, Parkinson maladie, Dyskinésie, Antiarythmique, Antiparkinsonien.

English descriptors

KwdEn :
- Adenosine, Adenosine receptor, Animal, Antiarrhythmic agent, Antiparkinson agent, Dopamine, Dopamine receptor, Dyskinesia, Glutamate receptor, Levodopa, Locomotion, Metabotropic receptor, Parkinson disease, Rat, mglu5 glutamate receptor.

Abstract

The pathophysiology of Parkinson's disease and L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia are characterised by an imbalance between activity of the direct and indirect pathways regulated by dopamine Dl and D2 receptors, respectively. In this study, we investigated the effects of treatments combining adenosine A₁ and metabotropic glutamate 5 (mGlu5) receptors modulators on locomotion induced by dopamine Dl receptor activation in the reserpine-treated rats. Administration of the adenosine A₁ receptor agonist and mGlu5 receptor antagonist resulted in the significant reduction of dopamine D1 receptor agonist-induced locomotion. The combination of adenosine A₁ receptor agonist with mGlu5 receptor antagonist had no greater effect than these compounds alone. However, the adenosine A₁ receptor antagonist attenuated the inhibitory effect of mGlu5 receptor antagonist. The data suggest that the effect of mGlu5 receptor blockade on locomotion elicited by dopamine Dl receptor stimulation involves activation of adenosine A₁ receptors. This interaction can improve our understanding of pathophysiology of L-DOPA-induced dyskinesia.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The pathophysiology of Parkinson's disease and L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia are characterised by an imbalance between activity of the direct and indirect pathways regulated by dopamine Dl and D2 receptors, respectively. In this study, we investigated the effects of treatments combining adenosine A<sub>1</sub>
 and metabotropic glutamate 5 (mGlu5) receptors modulators on locomotion induced by dopamine Dl receptor activation in the reserpine-treated rats. Administration of the adenosine A<sub>1</sub>
 receptor agonist and mGlu5 receptor antagonist resulted in the significant reduction of dopamine D1 receptor agonist-induced locomotion. The combination of adenosine A<sub>1</sub>
 receptor agonist with mGlu5 receptor antagonist had no greater effect than these compounds alone. However, the adenosine A<sub>1</sub>
 receptor antagonist attenuated the inhibitory effect of mGlu5 receptor antagonist. The data suggest that the effect of mGlu5 receptor blockade on locomotion elicited by dopamine Dl receptor stimulation involves activation of adenosine A<sub>1</sub>
 receptors. This interaction can improve our understanding of pathophysiology of L-DOPA-induced dyskinesia.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Effects of adenosine A1, dopamine D1 and metabotropic glutamate 5 receptors-modulating agents on locomotion of the reserpinised rats

Effects of adenosine A1, dopamine D1 and metabotropic glutamate 5 receptors-modulating agents on locomotion of the reserpinised rats

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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